葛金芳，教授

研究方向：神经药理学

联系电话：13865909561

电子邮箱：gejinfang@ahmu.edu.cn

办公室：知行楼B座1505室

教育经历：

1.2006/09 - 2012/11,中国科学技术大学,神经生物学,博士

2.2001/09 - 2004/06,维多利亚老品牌vic3308,药理学,硕士

工作经历：

1.2017-12至今,维多利亚老品牌vic3308,维多利亚老品牌vic3308,教授

2.2018/08 - 2019/08,美国东北俄亥俄医科大学,维多利亚老品牌vic3308,访学

3.2012/07 - 2017/11,维多利亚老品牌vic3308,维多利亚老品牌vic3308,副教授

4.2014/01 - 2014/02,澳大利亚塔斯马尼亚大学,维多利亚老品牌vic3308,访学

5.2006/07 - 2012/06,维多利亚老品牌vic3308,维多利亚老品牌vic3308,讲师

6.2004/07 - 2006/06,维多利亚老品牌vic3308,维多利亚老品牌vic3308,助教

7.1992/06-2001/08，维多利亚老品牌vic3308，第一附属医院

近5年学术荣誉：

1.安徽省教学成果二等奖（第一完成人，2024）

2.安徽省教学成果一等奖（第一完成人，2020）

3.安徽省教学创新团队负责人（2023）

4.安徽省教学名师（2022）

5.维多利亚老品牌vic3308十佳基础教师（2023）

6.维多利亚老品牌vic3308悦群十佳创新科技工作者 （2022）

7.维多利亚老品牌vic3308教学贡献新华奖（2020）

8.维多利亚老品牌vic3308优秀研究生导师（2020）

9.2023、2024年度“全球前2%顶尖科学家榜单”

10.学术兼职中国药学会、中国药理学会、中国神经科学学会会员。

近5年主持课题项目情况：

1.国家自然科学基金面上项目（81870403）：Nesfatin-1通过肝-脑轴固有巨噬细胞miRNA-34a- TREM2/DAP12- Wnt/ β-catenin信号通路调控NAFLD大鼠的脂质代谢紊乱及神经精神行为异常，2019-2022年，已结题，主持

2.安徽省高等学校科学研究重点项目（2024AH050773）：线粒体动力蛋白Drp1驱动的海马小胶质细胞线粒体稳态失衡在抑郁症发病机制中的作用，2025-2026，在研，主持

3.安徽省高校学科（专业）拔尖人才学术资助项目（gxbjZD2022013）：松果体素通过调节海马小胶质细胞BMAIL/CLOCK-BDNF- TREM2-Wnt/β-catenin信号通路改善NAFLD大鼠的神经精神损伤，2022年-2024年，已结题，主持

4.安徽省高校合作攻关和公共卫生协同创新重点科研平台支持项目（GXXT-2020-062）：抗癫痫γ-氨基丁酸(GABA)类似物的合成、生物活性及成药性研究，2020-2022年，已结题，主持

5.维多利亚老品牌vic3308科研水平提升计划（2022xkjT009）：褪黑素通过调节VMH-SCN-vHPC神经环路改善T2DM昼夜节律紊乱及认知功能损伤，2023年-2025年，在研，主持

近5年发表论文情况：

1.Ma MD，Fan M, Xu SL, Zheng Q, Wang CY, Chen PQ, Wei YD, Ge JF (通讯作者). Melatonin alleviates the retinal injury induced by vigabatrin and partly enhances its antiepileptic effects. Int Immunopharmacol. 2025 Apr 21;153: 114516.

2.Zheng Q, Xu SL, Guo XL, Wang CY, Ma MD, Ge JF (通讯作者). Effects of melatonin on the pharmacokinetics and amino acid metabolism profile of vigabatrin in rats. Toxicol Appl Pharmacol. 2025 Jan 28:117247

3.Sun HZ, Gao X, Niu JC, Chen PQ, He S, Xu SL, Ge JF (通讯作者). AD-like neuropsychiatric dysfunction in a mice model induced by a combination of high-fat diet and intraperitoneal injection of streptozotocin. eNeuro. 2024 Dec 3: ENEURO. 0310-24.2024.

4.Gao WF, Gao YJ, Xu YY, Liang J, Sun YH, Zhang YY, Shan F, Ge JF (共同通讯作者), Xia QR. Effect of duloxetine on changes in serum proinflammatory cytokine levels in patients with major depressive disorder. BMC Psychiatry. 2024 Jun 14;24(1):449. 

5.Gao YJ, Ling Y, Li J, Xu YY, Ge JF (共同通讯作者), Xia QR. Neuropathological implication of high blood bilirubin in patients and model rats with depression. Brain Res Bull. 2024 Jul 9:111028. 

6.Gao XR, Sun HZ, Wei YD, Hao SW, Niu JC, Sun HM, Tang GZ, Qi CC, Ge JF (通讯作者). Protective effect of melatonin against metabolic disorders and neuropsychiatric injuries in type 2 diabetes mellitus mice. Phytomedicine. 2024 Jun 4:131:155805.

7.He S, Yu Y, Chen P Q, Sun HM, Gao XR, Sun HZ, Ge JF (通讯作者).  Insufficient plasma melatonin and its association with neuropsychiatric impairments in patients with T2DM. J Diabetes Res. 2024 Jul 3; 2024:5661751. 

8.Xu SL, Fan M, Ma MD, Zheng Q, Chen PQ, Wei YD, Sun HM, Sun HZ, Ge JF (通讯作者). Differential toxic and antiepileptic features of Vigabatrin raceme and its enantiomers. Brain Res. 2024 May 14; 1838:148991. 

9.Xu DD, Hou ZQ, Xu YY, Liang J, Gao YJ, Zhang C, Guo F, Huang DD, Ge JF (通讯作者), Xia QR. Potential role of Bmal1 in Lipopolysaccharide-Induced Depression-like behavior and its associated "Inflammatory Storm". J Neuroimmune Pharmacol. 2024; 19, 4

10.Zheng Q, He S, Xu SL, Ma MD, Fan M, Ge JF (通讯作者). Pharmacokinetics and tissue distribution of vigabatrin enantiomers in rats. Saudi Pharm J. 2024 Feb;32(2):101934.

11.Li Q, Wang HX, Yang QL, Zhang L, Dai FC, Yu LJ, Wu L, Ge JF (共同通讯作者), Zhu P. Association of gestational cardiovascular health with infant neurodevelopment: A prospective study in Hefei of Anhui, China. Prev Med Rep. 2024 Jan 3; 38:102586. 

12.Ma RR, Wang P, Yang QL, Zhu YY, Zhang L, Wang YH, Sun LJ, Li WX, Ge JF (共同通讯作者), Zhu P. Interpregnancy interval and early infant neurodevelopment: the role of maternal-fetal glucose metabolism. BMC Med. 2024 Jan 2;22(1):2.

13.Li Q, Wang HX, Sun LJ, Wang P, Yin WJ, Ma SS, Tao RX, Ge JF (共同通讯作者), Zhu P. The mediating role of inflammation in the association between pregnancy loss history and gestational diabetes mellitus. Diabetol Metab Syndr. 2023 Jun 21;15(1):132.

14.Gao XR, Sun HZ, Hao SW, Sun HM, Ge JF (通讯作者). Melatonin protects HT-22 cells against palmitic acid-induced glucolipid metabolic dysfunction and cell injuries: Involved in the regulation of synaptic plasticity and circadian rhythms, Biochem Pharmacol. 2023 Oct 5: 115846.

15.Xu DD, Xu YY, Gao XR, Yan MY, Zhang C, Wu X, Xia QR, Ge JF (通讯作者). Potential value of Interleukin-6 as a diagnostic biomarker in human MDD and the antidepressant effect of its receptor antagonist tocilizumab in lipopolysaccharide-challenged rats. Int Immunopharmacol. 2023 Sep 15;124 (Pt B):110903.

16.Gao XR, Wei YD, Sun HZ, Hao SW, Ma MD, Sun HM, Zang DD, Qi CC, Ge JF (通讯作者). Role of Bmal1 in Type 2 Diabetes Mellitus-Related Glycolipid Metabolic Disorder and Neuropsychiatric Injury: Involved in the Regulation of Synaptic Plasticity and Circadian Rhythms. Mol Neurobiol. 2023 Aug; 60(8): 4595-4617.

17.Zheng Q, Han YX, Fan M, Gao XR, Ma MD, Xu JX, Liu S, Ge JF (通讯作者). Potential role of TREM2 in high cholesterolinduced cell injury and metabolic dysfunction in SHSY5Y cells. Exp Ther Med 2023 25: 205

18.Xu YY, Liang J, Sun YH, Zhang YY, Shan F, Ge JF (共同通讯作者), Xia QR. Serum cytokines-based biomarkers in the diagnosis and monitoring of therapeutic response in patients with major depressive disorder. Int Immunopharmacol. 2023 Mar 31; 118:110108. 

19.Ma SS, Yin WJ, Wang P, Wang HX, Zhang L, Jiang XM, Zhang Y, Tao RX, Ge JF (共同通讯作者), Zhu P. Previous pregnancy loss and gestational cardiovascular health: A prospective cohort of nulliparous women. Front Public Health. 2023 Apr 11; 11:1071706.

20.Sun HM, Yu Y, Gao XR, Wei YD, Qi CZ, Ma MD, Xu DD, Xu YY, Ge JF (通讯作者). Potential role of 25(OH)D insufficiency in the dysfunction of glycolipid metabolism and cognitive impairment in patients with T2DM. Frontiers in endocrinology. 2022 Dec 23;13: 1068199.

21..Liu S, Fan M, Ma MD, Ge JF (通讯作者). Chen FH. Long non-coding RNAs: Potential therapeutic targets for epilepsy. Front Neurosci. 2022 Oct 6;16: 986874.

22.Liu S , Fan M , Xu JX, Yang LJ, Qi CC, Xia QR, Ge JF (通讯作者). Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology. J Neuroinflammation. 2022;19(1):35. (ESI高被引论文)

23.Liu S, Fan M, Zheng Q, Hao SW, Yang LJ, Xia QR, Qi CC, Ge JF (通讯作者). MicroRNAs in Alzheimer's disease: potential diagnostic markers and therapeutic targets. Biomedicine & Pharmacotherapy. 2022;112681. (ESI高被引论文)

24.Fan M, Liu S, Sun HM, Ma MD, Gao YJ, Qi CC, Xia QR, Ge JF (通讯作者). Bilateral intracerebroventricular injection of streptozotocin induces AD-like behavioral impairments and neuropathological features in mice: Involved with the fundamental role of neuroinflammation.  Biomedicine & Pharmacotherapy. 2022;113375.

25.Wei YD, Chen XX, Yang LJ, Gao XR, Xia QR, Qi CC, Ge JF (通讯作者). Resveratrol ameliorates learning and memory impairments induced by bilateral hippocampal injection of streptozotocin in mice. Neurochem Int. 2022 Jul 14:105385.

26.Gao WF, Xu YY, Liang J, Sun YH, Zhang YY, Shan F, Ge JF (共同通讯作者), Xia QR. Comparison of serum cytokines levels in normal-weight and overweight patients with first-episode drug-naïve major depressive disorder. Front. Endocrinol. 2022; 13:1048337

27.Xu YY, Liang J, Gao WF, Sun YH, Zhang YY, Shan F, Ge JF (共同通讯作者), Xia QR. Peripheral blood cytokines as potential diagnostic biomarkers of suicidal ideation in patients with first-episode drug-naïve major depressive disorder. Front. Public Health. 2022; 10:1021309

28.Gao WF, Xu YY, Liang J, Sun YH, Zhang YY, Shan F, Ge JF (共同通讯作者), Xia QR. Serum CC Chemokines as Potential Biomarkers for the Diagnosis of Major Depressive Disorder. Psychology Research and Behavior Management 2022:15

29.Xu DD, Yu Y, Xu YY, Ge JF (通讯作者). Plasma Nesfatin-1: Potential Predictor and Diagnostic Biomarker for Cognitive Dysfunction in T2DM Patient. Diabetes Metab Syndr Obes. 2021 Aug 10; 14:3555-3566. 

30.Gao XR, Chen Z, Fang K, Xu JX, Ge JF (通讯作者). Protective effect of quercetin against the metabolic dysfunction of glucose and lipids and its associated learning and memory impairments in NAFLD rats. Lipids in Health and Disease 2021; 20:164.

31.Xu JX, Fang K, Gao XR, Liu S, Ge JF (通讯作者). Resveratrol Protects SHSY5Y Cells Against Oleic AcidInduced Glucolipid Metabolic Dysfunction and Cell Injuries Via the Wnt/βCatenin Signalling Pathway. Neurochem Res. 2021; 46:2936-2947

32.Qi CC, Chen XX, Gao XR, Xu JX, Liu S, Ge JF (通讯作者). Impaired Learning and Memory Ability Induced by a Bilaterally Hippocampal Injection of Streptozotocin in Mice: Involved With the Adaptive Changes of Synaptic Plasticity. Front. Aging Neurosci. 2021 May 1; 13: 633495.

33.马梦蝶，樊敏，徐松林，郑强，何帅，葛金芳（通讯作者）．红藻氨酸诱导大鼠癫痫发作及神经精神行为异常的性别差异．中国实验动物学报, 2024,

34.方可，刘猛，葛金芳（通讯作者）.外泌体miRNA在双相情感障碍中的作用及其诊断和治疗潜力.中华精神科杂志, 2024, 57(5):274-281

35.郑强，樊敏，葛金芳（通讯作者）.氨己烯酸的作用机制及代谢分布研究进展.中国新药杂志,2023,32(13):1351-1357.

36.高欣冉，葛金芳（通讯作者）.脑源性神经营养因子在2型糖尿病认知功能障碍机制中作用的研究进展.中国糖尿病杂志,2022,30(04):305-309.

37.刘森，葛金芳（通讯作者）.外泌体在2型糖尿病发病机制及诊疗标志物开发中的研究进展.中国新药杂志. 2022. 31(03): 237-244.

38.徐静娴，刘森，高欣冉，高叶俊，夏清荣，葛金芳（通讯作者）.白藜芦醇通过调节BDNF/Akt/CREB及TREM1/2表达失衡抑制脂多糖诱导的BV2小胶质细胞炎症反应.中国药理学通报. 2021, 37(10): 1402-1408.

39.刘森，陈征，高欣冉，彭磊，葛金芳（通讯作者）.高脂饮食对大鼠海马形态及突触相关蛋白Synapsin-1表达的影响.维多利亚老品牌vic3308学报. 2021; 56(06):862-866.

近5年授权专利情况:

1.葛金芳，陈飞虎，樊敏，郑强，马梦蝶，高欣冉，徐松林，何帅.褪黑素在制备抗癫痫药物中的应用及制备的抗癫痫和改善视网膜毒性的药物.中华人民共和国国家知识产权局发明专利申请，专利号：202211509837.X，授权公告日：2024年04月30日，授权公告号：CN 115737640 B