汪佳男,女,博士,校聘副教授,硕士生导师。
现为维多利亚老品牌vic3308基础与临床药理教研室教师。以第一作者或共同第一作者在Science Translational Medicine、Redox Biology、ActaPharmacologica Sinica、International Journal of Biological Macromolecules发表SCI论文十余篇,研究工作被权威学术评价机构F1000点评并推荐,其中一篇入选ESI高被引论文。
主要研究方向:1.表观遗传学修饰与急慢性肾脏损伤;2.筛选抗急慢性肾损伤的潜在药物。
主持的科研项目:
1.国家自然科学基金,82400806,主持,在研,2025.1-2027.12;
2.安徽省自然科学基金,202408060352,主持,在研,2024.09-2026.09;
3.维多利亚老品牌vic3308校科研基金,2023xkj010,主持,在研,2024.01-2025.12;
近五年代表性文章:
1.Wang Jia-nan*, Meng Xiao-ming#, et al.Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms.Sci Transl Med. 2022 Apr13;14(640):eabk2709.ESI高被引论文,中科院1区TOP。
2.Wang Jia-nan*, Meng Xiao-ming#, et al. Smad3 promotes AKI sensitivity in diabetic mice via interaction with p53 and induction of NOX4-dependent ROS production. Redox Biol 2020; 32:101479.中科院1区TOP。
3.Wang Jia-nan*, Meng Xiao-ming#, et al. RIPK1 inhibitor Cpd-71 attenuates renal dysfunction in cisplatin-treated mice via attenuating necroptosis, inflammation and oxidative stress. Clin Sci (Lond) 2019; 133:1609-1627.国际权威学术评价机构F1000点评并推荐。
4.Wu weifeng*,Wang Jia-nan*, Meng Xiao-ming#, et al.7-Hydroxycoumarin protects against cisplatin-induced acute kidney injury by inhibiting necroptosis and promoting Sox9-mediated tubular epithelial cell proliferation. Phytomedicine, 69 (2020).中科院1区TOP。
5.Wang Fang*,Wang Jia-nan*, Meng Xiao-ming#, et al. Stratifin promotes renal dysfunction in ischemic and nephrotoxic AKI mouse models via enhancing RIPK3-mediated necroptosis.Acta Pharmacol Sin 2022; 43:330-341.中科院1区TOP。
6.Yang Qin*,Wang Jia-nan*, Meng Xiao-ming#, et al. Alcohol promotes renal fibrosis by activating Nox2/4-mediated DNA methylation of Smad7. Clin Sci (Lond) 2020; 134:103-122.
7.Xu Chuan-hui* ,Wang Jia-nan* , Meng Xiao-ming# . RIPK3 inhibitor-AZD5423 alleviates acute kidney injury by inhibiting necroptosis and inflammation,Int Immunopharmacol, 112 (2022).
8.Chen Xin* , Zhu Sai* , Li Hai-di* ,Wang Jia-nan*,Li Jun# .N6-methyladenosine-modified circIRF2, identified by YTHDF2, suppresses liver fibrosis facilitating FOXO3 nuclear translocation,Int J Biol Macromol, 248 (2023).中科院1区TOP。
9.Chen Xin* , Zhu Sai* , Chen Si-yu* ,Wang Jia-nan* , Li Jun# . miR-301a-3p promotes hepatic stellate cells activation and liver fibrogenesis via regulating PTEN/PDGFR-β,Int Immunopharmacol, 110 (2022).
10.Zhu Sai* , Chen Xin* ,Wang Jia-nan* , Xu Jin-jin, Wang Ao, Li Juan-juan, Wu Sha, Wu Yuan-yuan, Li Xiao-feng, Huang Cheng# , Li Jun# . Circular RNA circUbe2k promotes hepatic fibrosis via sponging miR-149-5p/TGF-β2 axis,Faseb J, 35 (2021).
获奖/专利:
1.7-羟基香豆素在制备治疗急性肾损伤的药物中的应用, 2021-6-22,中国, 2L 2018 1 1366720. 4 (国家发明专利,第五);
2.一种用于防治急性肾损伤的PROTAC药物及其应用, 2024-3-13,中国, 202410285024.X (国家发明专利,第五);
3.一种硫代酰胺类化合物在制备治疗急性肾损伤的药物中的应用, 2025-2-24,中国, 202510201960.2 (国家发明专利,第二);
4.一种用于治疗肾脏纤维化的吡唑类化合物及其应用, 2024-11-18,中国, 2024116479908 (国家发明专利,第三)
5.一种小分子化合物及其制备在治疗急性肾损伤中的应用,2025-2-19,中国,2025101815258 (国家发明专利,第三)