李维祖，博士，教授，博士生导师

在维多利亚老品牌vic3308药学科学学院药理学教研室从事教学和科研工作，2015年-2016年在美国北方德克萨斯大学健康科学中心做访问学者一年。研究方向为神经药理学和内分泌药理学，主要从事老年性痴呆、II型糖尿病神经系统和肾脏并发症及人参皂苷Rg1的保护作用研究。近年来主持国家自然科学基金面上项目2项，主持安徽省自然科学基金重点项目1项，安徽省教育厅重大项目1项。发表SCI论文三十余篇，其中一篇论文被评为“维多利亚老品牌vic33082016年度最具影响力十佳论文”。承担了维多利亚老品牌vic3308临床医学专业、麻醉等专业、留学生的药理学、麻醉药理学等教学，2013和2023年获维多利亚老品牌vic3308优秀教师荣誉称号。

研究方向：神经药理学，包括阿尔茨海默病、糖尿病认知功能障碍等

电子邮箱：liweizu@126.com

主持课题项目情况：

1.安徽省科学技术厅,面上项目, 2208085MH219,基于PLC-CaN-NFAT1信号通路研究人参皂苷Rg1抑制神经元Aβ生成的作用及机制, 2022-01至2024-12, 10万元,资助期满,主持。

2.安徽省高校自然科学研究重大项目，KJ2020ZD14，化药1类新药—HY-021068防治阿尔茨海默病的作用及机制研究，2021/01-2023/12，20万元，已结题，主持。

3.国家自然科学基金面上项目，81671384，NADPH氧化酶介导的NLRP-1炎症小体激活在脑老化认知功能障碍中的作用及人参皂苷Rg1的调节作用，2017/01-2018/12，25万元，已结题，主持。

4.国家自然科学基金面上项目，81371329，糖皮质激素对海马神经元NLRP1炎症小体的调节作用及在海马神经元损伤中的作用，2014/01-2017/12，70万元，已结题，主持。

发表论文情况：

1.Liangliang Kong, Yan Liu, Jingwei Li, Yanyan Wang, Pengmin Ji, Qifeng Shi, Min Han, Hanyang Xu, Weiping Li, Weizu Li. Ginsenoside Rg1 alleviates chronic inflammation-induced neuronal ferroptosis and cognitive impairments via regulation of AIM2 - Nrf2 signaling pathway.J Ethnopharmacol. 2024, 330:118205.

2.Huimin Zhou, Yan Liu, Yong Su, Pengmin Ji, Liangliang Kong, Ran Sun, Duoduo Zhang, Hanyang Xu, Weiping Li,Weizu Li. Ginsenoside Rg1 attenuates lipopolysaccharide-induced chronic liver damage by activating Nrf2 signaling and inhibiting inflammasomes in hepatic cells. J Ethnopharmacol. 2024, 324:117794.

3.Ye Huang, Min Han, Qifeng Shi, Xuewang Li, Jiajia Mo, Yan Liu, Zhaoxing Chu,Weizu Li. HY-021068 alleviates cerebral ischemia-reperfusion injury by inhibiting NLRP1 inflammasome and restoring autophagy function in mice.Exp Neurol. 2024, 371:114583.

4.Ran Sun, Min Han, Yan Liu, Yong Su, Qifeng Shi, Lei Huang, Liangliang Kong,Weizu Li, Weiping Li.Trpc6 knockout protects against renal fibrosis by restraining the CN NFAT2 signaling pathway in T2DM mice.Mol Med Rep. 2024, 29(1):13.

5.黄蕾，汪燕燕，孙冉，周慧敏，姬朋敏，孔亮亮，李卫平，李维祖.人参皂苷Rg1通过抑制MAPK-NLRP1通路减轻2型糖尿病诱导的神经元损伤.中国药理学通报, 2023, 39(11):2034-2042.

6.Liangliang Kong, Ran Sun, Huimsin Zhou, Qifeng Shi, Yan Liu, Min Han, Weiping Li, Sen Qun,Weizu Li. Trpc6 knockout improves behavioral dysfunction and reduces Aβ production by inhibiting CN-NFAT1 signaling in T2DM mice. Exp Neurol. 2023, 363:114350.

7.Xuewang Li, Han Zhang, Liu Yang, Xianan Dong, Yuli Han, Yong Su, Weiping Li,Weizu Li. Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice.Behav Brain Funct. 2023, 19(1):7.

8.Hu Xu,Weizu Li, Lei Huang, Xinyu He, Bei Xu, Xueqing He, Wentong Chen, Yaoxing Wang, Wenjun Xu, Sheng Wang, Qin Kong, Youzhi Xu, Wenjie Lu. Phosphoethanolamine cytidylyltransferase ameliorates mitochondrial function and apoptosis in hepatocytes in T2DM in vitro.J Lipid Res. 2023, 64(3):100337.

9.Yuli Han, Yong Su, Min Han, Yan Liu, Qifeng Shi, Xuewang Li, Penghui Wang, Weiping Li,Weizu Li. Ginsenoside Rg1 attenuates glomerular fibrosis by inhibiting CD36/TRPC6/NFAT2 signaling in type 2 diabetes mellitus mice.J Ethnopharmacol. 2023, 302(Pt A):115923.

10.Xianan Dong, Liangliang Kong, Lei Huang, Yong Su, Xuewang Li, Liu Yang, Pengmin Ji, Weiping Li,Weizu Li. Ginsenoside Rg1 treatment protects against cognitive dysfunction via inhibiting PLC-CN-NFAT1 signaling in T2DM mice.J Ginseng Res. 2023, 47(3):458-468.

11.Zhenghao Sun, Fei Liu, Liangliang Kong, Pengmin Ji, Lei Huang, Huimin Zhou, Ran Sun, Jing Luo,Weizu Li. Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm.Biomed Pharmacother. 2023, 161:114480.

12.Zhenghao Sun, Xuewang Li, Liu Yang, Xianan Dong, Yuli Han, Yan Li, Jing Luo,Weizu Li. SOCE-mediated NFAT1-NOX2-NLRP1 inflammasome involves in lipopolysaccharide-induced neuronal damage and Aâ generation.Mol Neurobiol. 2022, 59(5):3183-3205.

13.Jing Luo, Xiaoqun Zhu, Fei Liu, Liang Zhao, Zhenghao Sun, Yan Li, Lei Ye,Weizu Li. Expression of serum miR-126 in patients with intracranial aneurysm and its relationship with postoperative cerebral vasospasm.Am J Transl Res. 2022, 14(6):4372-4379.

14.Yuli Han, Xuewang Li, Liu Yang, Duoduo Zhang, Lan Li, Xianan Dong, Yan Li, Sen Qun,Weizu Li. Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice.J Ginseng Res. 2022, 46(4):515-525.

15.Shixin Ding, Liu Yang, Lei Huang, Liangliang Kong, Ming Chen, Yong Su, Xuewang Li, Xianan Dong, Yuli Han, Weiping Li,Weizu Li. Chronic glucocorticoid exposure accelerates Aβ generation and neurotoxicity by activating calcium-mediated CN-NFAT1 signaling in hippocampal neurons in APP/PS1 mice.Food Chem Toxicol. 2022, 168:113407.

16.Liu Yang, Huimin Zhou, Lei Huang, Yong Su, Liangliang Kong, Pengmin Ji, Ran Sun, Chao Wang, Weiping Li,Weizu Li. Stress level of glucocorticoid exacerbates neuronal damage and Aβ production through activating NLRP1 inflammasome in primary cultured hippocampal neurons of APP-PS1 mice.Int Immunopharmacol. 2022, 110:108972.