张贵阳，博士，副教授

  2018年毕业于南京大学，获博士学位。

  长期从事药物靶向递送组装体系研究。主持安徽省面上项目、安徽省教育厅项目、安徽省转化医学研究院培育项目及维多利亚老品牌vic3308基础与临床合作研究项目各1项；发表科研文章30余篇，其中SCI收录30篇。以第一作者或通讯作者身份在Nature Communications、Small、Chemical Engineering Journal、Advanced Healthcare Materials、ACS Applied Materials & Interfaces等期刊发表多篇研究成果；以最后通讯作者身份受邀发表两篇关于COF在递送小分子或大分子药物中的综述。独立撰写英文著作章节Covalent Organic Frameworks（ISBN 978-1-80356-960-4；DOI: 10.5772/intechopen.102264）；获授权国家专利三项；2023年入选Asian Journal of Pharmaceutical Sciences、Exploration、iMeta和Biomaterials Translational青年编委。至今已指导毕业硕士研究生6名，其中全部荣获“国家奖学金”。

邮箱：guiyangzhang@ahmu.edu.cn

工作经历：

1.2020.9 -至今  维多利亚老品牌vic3308，基础医学院，工作，副教授

2.2015.10-2020.09  南京大学，高分子化学与物理，导师：贾叙东，袭锴教授

主持或参加科研项目：

(1)安徽省转化医学研究院,培育项目, 2022zhyx-C13,主动透皮释药COFs贴片技术开

发, 2023-01至2025-12, 8万元,在研,主持

(2)维多利亚老品牌vic3308,维多利亚老品牌vic3308基础与临床合作研究项目, 2021xkjT024,基于COFs的

纳米药物载体设计及其用于肾癌脑转移治疗的研究, 2022-01至2024-12, 20万元,在研,

主持

(3)安徽省高等学校自然科学研究项目,重点项目, KJ2019A0942,基于刺激-触发开关诱

导聚集的苯硼酸脂生物响应材料的设计、制备与性能研究, 2019-07至2021-07, 6万元,

结题,主持

(4)安徽省自然科学基金项目，面上项目，2408085MH196，糖基化蛋白捕获与活性氧清除COF体系的构建及其调控巨噬细胞抗糖尿病心肌病的研究，2024-09-01至2027-08-31，8万元，在研，主持

研究方向:药物靶向递送

代表性论文与专著（通讯作者*）：

[1]Guiyang Zhang, Xinle Li, Qiaobo Liao, Yanfeng Liu, Kai Xi*, Wenyu Huang* Xudong Jia*. Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery.Nature Communications,2018, 9, 2785.  (IF: 14.7)

[2] Jin Wu, Tao Meng, Xiaoqian Zhang, Songtao Tang, Lei Liu, Jing Xue, Xiaohui Liu, Junjun Wang, Jiyue Wen*, Danyou Hu*,Guiyang Zhang*. Glucose‐Responsive Zn(II)‐Porphyrin COF Adhesive Hydrogels With Dual‐Active Sites and GOX‐Like Activity for Accelerated Wound Healing. Advanced Healthcare Materials,2025, 2404076.  (IF: 10)

[3]Chen Wang, Junyan He, Zhongyao Hu, Yiqun Yan, Zelin Xu, Yangmang Yu, Jingwen Su, Bing Ma, Haoran Yu*,Guiyang Zhang*, Wendan Cheng*. An injectable reactive oxygen species-responsive self-assembled hydrogel loaded with L-glutamine targets cartilage repair for treatment of osteoarthritis. Chemical Engineering Journal,2025, 505, 159529.  (IF: 13.4)

[4] Saisai Ge, Xinyue Wang, Xinru Zhao, Lingling Yuan, Xuewei Bao, Caidie Sun, Zehua Gong, Jun Guo, Siyu Yuan, Danyou Hu, Jing Yang*, Bin Yuan*,Guiyang Zhang*. Responsive Multi-Arm PEG-Modified COF Nanocomposites: Dynamic Photothermal, pH/ROS Dual-Responsive, Targeted Carriers for Rheumatoid Arthritis Treatment, Advanced Healthcare Materials,2024, 2401744.  (IF: 10)

 [5] Jialu Zhuang, Hao Zhang, Jin Wu, Danyou Hu, Tao Meng, Jing Xue, Hanyang Xu, Gang Wang*, Hua Wang*,Guiyang Zhang*. Redox-Responsive AIEgen Diselenide-Covalent Organic Framework Composites Targeting Hepatic Macrophages for Treatment of Drug-induced Liver Injury. Small.2024. 2402656.  (IF: 13)

[6] Jing Xue, Jialu Zhuang, Xinyue Wang, Tao Meng, Jin Wu, Xiaoqian Zhang, andGuiyang Zhang*. Mechanisms and Therapeutic Strategies for Myocardial Ischemia-Reperfusion Injury in Diabetic States. ACS Pharmacology & Translational Science.2024, DOI: 10.1021/acsptsci.4c00272.  (IF: 5.1)

[7] Neng Jin, Jin Wu, Shuming Ye*, Jing Xue, Tao Meng, Liang Hu, Shangshang Jiang, Hanyang Xu, Yue Yu*, Danyou Hu*,Guiyang Zhang*. Injectable Dynamic ROS-Responsive COF-Modified Microalgae Gels for In Vivo bFGF Delivery to Treat Diabetic Wounds. ACS Applied Materials & Interfaces,2024, 16, 15, 18608–18626.  (IF: 8.5)

[8] Tao Meng, Xinyue Wang, Shangshang Jiang, Si-rui Chen, Shengnan Zhou, Yuheng Zhu, Jin Wu, Danyou Hu*, Yuwen Yan, andGuiyang Zhang*. Delivery of Small-Molecule Drugs and Protein Drugs by Injectable Acid-Responsive Self-Assembled COF Hydrogels for Combinatorial Lung Cancer Treatment.ACS Applied Materials & Interfaces2023, 15, 36, 42354-42368.  (IF: 8.5)

[9]Shengnan Zhou, Tian Tian, Tao Meng, Jin Wu, Danyou Hu, Qiaobo Liao, Jialu Zhuang, Hua Wang*, andGuiyang Zhang*. Tumor-derived covalent organic framework nanozymes for targeted chemo-photothermal combination therapy.iScience,2023, 26, 107348.  (IF: 4.6)

[10]英文著作章节撰写: Covalent Organic Frameworks (ISBN 978-1-80356-960-4)2022, DOI: 10.5772/intechopen.102264 InTech Open. Chapter title: Applications of Covalent Organic Frameworks (COFs) in Oncotherapy. Authors: Dr. Guiyang Zhang*

专利与技术许可：

1.高杉;张贵阳;黄晨光;周胜南;李文雯COFs复合材料、缓释体系及其在制备用于治疗MI/R损伤的药物中的应用，专利号：ZL 2022 1 0062428.3

2.多孔复合材料长效控糖体系、其制备方法和用途，高杉，张贵阳，宋梦梦，王小云 专利号：ZL 2019 1 1069 108.52019

3.负载抗肿瘤药物的纳米复合材料、纳米载药体系及制备与应用张贵阳，胡丹优，周胜南，朱玉恒，孟涛 专利号：ZL 2022 1 0795376.0