张骏艳,博士,副教授,硕士研究生导师
中国药理学会会员,安徽省药理学会会员。自2005年起在维多利亚老品牌vic3308从事药理学的教学科研工作。主讲《药理学》、《临床药理学》、《麻醉药理学》等课程,主持或参与多项安徽省教学质量工程项目。主持或参与多项国家自然科学基金项目、安徽省自然科学基金项目、安徽省高校自然科学研究项目。主要研究成果发表于Phytomedicine、J Ethnopharmacol等SCI期刊上。
研究方向:1.心脑血管药理学;2.抗炎免疫药理学
联系方式:zjy404.student@sina.com
一、科研项目:
1.2019年度安徽省高校自然科学研究项目(重点项目):自噬与NLRP1炎症小体交互调控在心肌梗死后心室重构中的作用研究(主持)
2.2016年度国家自然基金面上项目:NADPH氧化酶介导的NLRP1炎症小体激活在脑老化认知功能障碍中的作用及人参皂苷Rg1的调节作用(参与)
3.2016年度安徽省高校自然科学研究项目(重点项目):靶向调控Shh信号通路抑制心肌缺血再灌注诱导心肌细胞凋亡的作用及机制研究(主持)
二、主要发表论文:
1. Rao TC,Tong H,Li J, Huang JH, Yin Yy,Zhang JY*Exploring the role and mechanism of hyperoside against cardiomyocyte injury in mice with myocardial infarction based on JAK2/STAT3 signaling pathway,Phytomedicine, 2024 Jun:128:155319.
2. Yang YK, Li J,Rao TC,Fang ZR,Zhang JY*.The role and mechanism of hyperoside against myocardial infarction in mice by regulating autophagy via NLRP1 inflammation pathway.J Ethnopharmacol.2021 Aug 10;276; 114187
3. Yang HH, Xue W, Ding CJ, Wang C, Xu BH, Chen S, Zha BS, Sun YQ, Zhu HQ, ZhangJY*, Dong LY*. Vitexin Mitigates Myocardial Ischemia/Reperfusion Injury in Rats by Regulating Mitochondrial Dysfunction via Epac1-Rap1 Signaling.Oxid Med Cell Longev 2021 Jun 28;2021:9921982.
4. Cheng XQ#,Zhang JY#, Wu H, Zuo YM, Tang LL, Zhao Q, Gu EW.Outcomes of individualized goal-directed therapy based on cerebral oxygen balance in high-risk patients undergoing cardiac surgery: A randomized controlled trial.J Clin Anesth.2020 Sep 1;
5. Cheng XQ#,Zhang JY#, Gao SS, Wu H,Zuo YM, Gu EW, Chen ZW. Sufentanil attenuates impairment of the endothelium-dependent vasodilation induced by hypoxia-reoxygenation in the rat coronary artery.Can J Pharmacol.2016;94(12):1309-1314
6. Jiao Y, Fan YF, Wang YL,Zhang JY, Chen S, Chen ZW. Protective Effect and Mechanism of Total Flavones from Rhododendron simsii Planch Flower on Cultured Rat Cardiomyocytes with Anoxia and Reoxygenation.Evid Based Complement Alternat Med.2015;5.
7.Che X, Wang X, , Peng CF, Zhen YL, Shao X, Zhang GL, Dong LY. Vitexin exerts cardioprotective effect on chronic myocardial ischemia/reperfusion injury in rats via inhibiting myocardial apoptosis and lipid peroxidation.Am J Transl Res Actions. 2016 Aug 15;8(8):3319-28.
8.Zhang JY,Chen ZW, Yao H.Protective effect of urantide against ischemia-reperfusion injury via protein C and phosphtidylinositol 3’-kinase-Akt passway.Can J Physiol Pharmacol, 2012,90(5):637-645
9.杨永康,李静,饶廷彩,张骏艳*.金丝桃苷通过调节自噬水平减轻心肌梗死小鼠心脏及胸主动脉的损伤[J].中国临床药理学与治疗学,2021,26(6):601-608