文继月，博士，副教授，硕士生导师

研究方向：神经药理学

联系电话：18256510760

电子邮箱：wenjiyue139@aliyun.com

主持课题项目情况：

1.H₂S调控RhoA-ROCK/PKA/BK_Ca信号通路介导星形胶质细胞活化为抗炎表型，安徽省高校自然科学研究项目，主持，在研。

2. H₂S促进A2型星形胶质细胞活化在映山红花总黄酮抗缺血性脑中风中的作用及机制研究，安徽省自然科学基金，主持，在研。

3.神经源性H₂S抑制RhoA/ROCK2通路在脑缺血后星形胶质细胞表型转换中的作用及机制研究，安徽省高校自然科学研究项目，主持，已结题。

4.戊型肝炎病毒基因特异性中和抗原表位与免疫逃逸的研究，维多利亚老品牌vic3308博士科研资助项目，主持，已结题。

5.基于循环血液外泌体RNA的前列腺癌早期诊断标志物的筛选与鉴定及相关试剂盒的研发，安徽省转化医学研究院科研基金项目，合作主持，已结题。

发表论文情况：

1. Zhifeng Geng, Guoyi Deng, Ziyu Wang, Xin Xu, Xiaojiao Yin, Sen Zhang, Jiale Shao, Jiyue Wen*. Distinct roles of A1/A2 astrocytes in blood-brain barrier injury following cerebral I/R via the ROCK/NF-κB and STAT3 pathways. International Immunopharmacology. 2025, 151:114338.

2. Weizhuo Lu and Jiyue Wen*. Metabolic reprogramming and astrocytes polarization following ischemic stroke. Free Radical Biology and Medicine. 2025, 228:197-206.

3. Weizhuo Lu and Jiyue Wen*. The relationship among H2S, neuroinflammation and MMP-9 in BBB injury following ischemic stroke. International Immunopharmacology. 2025, 146:113902.

4. Weizhuo Lu and Jiyue Wen*. Anti-inflammatory effects of hydrogen sulfide in axes between gut and other organs. Antioxidants & Redox Signaling. 2024 Dec 10, Online ahead of print.

5. Weizhuo Lu and Jiyue Wen*. Neuroinflammation and post-stroke depression: focus on the microglia and astrocytes. Aging and Disease. 2024, 16(1):394-407.

6. Weizhuo Lu and Jiyue Wen*. The roles of RhoA/ROCK/NF-κB pathway in microglia polarization following ischemic stroke. Journal of Neuroimmune Pharmacology. 2024, 16;19(1):19.

7. Jiyue Wen, Jie Zhang, Shuo Chen, Ye Chen, Yang Zhang, Ziyao Ma, Fang Zhang, Weiming Xie, Yifei Fan*, Jingsi Duan*, Zhiwu Chen*. Endothelium-derived hydrogen sulfide acts as a hyperpolarizing factor and exerts neuroprotective effects via activation of large-conductance Ca²⁺-activated K⁺ channels. British Journal of Pharmacology. 2021, 178(20):4155-4175.

8.Xiaojiao Yin, Bo Liu, Yanyu Ding, Xueyan Li, Ju Sheng, Yan Guo, Zhiwu Chen*, Jiyue Wen*. Total flavones of Rhododendron induce the transformation of A1/A2 astrocytes via promoting the release of CBS-produced H₂S. Phytomedicine. 2023,111:154666.

9.Yanyu Ding, Fang Fang, Xiaolong Liu, Shuyan Sheng, Xueyan Li, Xiaojiao Yin, Zhiwu Chen*, Jiyue Wen*. H₂S regulates the phenotypic transformation of astrocytes following cerebral ischemia/reperfusion via inhibiting the RhoA/ROCK pathway. Molecular Neurobiology. 2024, 61(6):3179-3197.

10.Weizhuo Lu, Zhiwu Chen* and Jiyue Wen*. The role of RhoA/ROCK pathway in the ischemic stroke-induced neuroinflammation. Biomedicine & Pharmacotherapy. 2023, 165:115141.

11. Xueyan Li, Xiaojiao Yin, Jiazhuang Pang, Zhiwu Chen* and Jiyue Wen*. Hydrogen sulfide inhibits lipopolysaccharide-based neuroinflammation-induced astrocyte polarization after cerebral ischemia/reperfusion injury. European Journal Pharmacology. 2023, 949:175743.

12. Weizhuo Lu and Jiyue Wen*. Crosstalk among glial cells in the blood-brain barrier injury after ischemic stroke. Molecular Neurobiology. 2024, 61(9):6161-6174. IF:4.6

13. Weizhuo Lu and Jiyue Wen*. H₂S-RhoA/ROCK pathway and glial cells in axonal remyelination after ischemic stroke. Molecular Neurobiology.2023, 60(9):5493-5504.

14. Yanyu Ding, Bo Liu, Yang Zhang, Fang Fang, Xueyan Li, Song Wang*, Jiyue Wen*. Hydrogen sulphide protects mice against the mutual aggravation of cerebral ischaemia/reperfusion injury and colitis. European Journal of Pharmacology. 2022, 914:174682.

15.Yang Zhang, Kexin Li, Xiangyi Wang, Yanyu Ding, Ziruo Ren, Jinglong Fang, Tao Sun, Yan Guo*, Zhiwu Chen*, Jiyue Wen*. CSE-Derived H₂S inhibits reactive astrocytes proliferation and promotes neural functional recovery after cerebral ischemia/reperfusion injury in mice via inhibition of RhoA/ROCK2 pathway. ACS Chemical Neuroscience. 2021,12(14):2580-2590.

16.Ye Chen, Jiyue Wen*, Zhiwu Chen*. H₂S protects hippocampal neurons against hypoxia-reoxygenation injury by promoting RhoA phosphorylation at Ser188. Cell Death and Discovery. 2021, 7(1):132.

17.Weizhuo Lu, Jiyue Wen*. H₂S-mediated inhibition of RhoA/ROCK pathway and noncoding RNAs in ischemic stroke. Metabolic Brain Disease. 2023, 38(1):163-176.

18.Weizhuo Lu, Zhiwu Chen*, Jiyue Wen*. RhoA/ROCK signaling pathway and astrocytes in ischemic stroke. Metabolic Brain Disease. 2021, 36(6):1101-1108.

19. Jinhua Chen, Xiaohong Ding, Wei Chen, Shuo Chen, Qianjun Guan, Jiyue Wen*, Zhiwu Chen*. VEGFR2 in vascular smooth muscle cells mediates H2S-induced dilation of the rat cerebral basilar artery. Microvascular Research. 2022, 141:104309.

20.Fang Zhang, Shuo Chen, Jiyue Wen*, Zhiwu Chen*. 3-Mercaptopyruvate sulfurtransferase/hydrogen sulfide protects cerebral endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury via mitoprotection and inhibition of the RhoA/ROCK pathway. American Journal Physiology Cell Physiology. 2020, 319(4):C720-C733.

21.Yan Guo, Xiaomeng Yu, Shuo Chen, Jiyue Wen*, Zhiwu Chen*. Total flavones of Rhododendron simsii Planch flower protect rat hippocampal neuron from hypoxia-reoxygenation injury via activation of BK channel. Journal of Pharmacy and Pharmacology. 2020,72(1):111-120.

22.Jiyue Wen, Shanshan Gao, Fanglin Chen, Shuo Chen, Mei Wang, Zhiwu Chen*. Role of CSE-Produced H2S on cerebrovascular relaxation via RhoA-ROCK inhibition and cerebral ischemia-reperfusion injury in mice. ACS Chemical Neuroscience. 2019, 20;10(3):1565-1574.

23.Jiyue Wen, Mei Wang, Yanan Li, Huihui Jiang, Xuanjun Sun, Zhiwu Chen*.Vascular protection of Hydrogen Sulfide on cerebral ischemia/reperfusion injury in rats. Frontiers in neurology. 2018, 9: 779.