邵君棠，博士，副教授，硕士生导师

  博士，副教授，硕士生导师，入选安徽省“百人计划”青年项目，获评省海外高层次人才。美国南加州大学医药科学博士，曾在全球知名药企美国勃林格殷格翰制药公司任高级研究员，从事创新药物研发和管理。2019年加入维多利亚老品牌vic3308药理学教研室，研究方向为肝脏疾病的病理机制及药物作用新靶点的发现、新型药物靶向递呈系统的研发，主持国家自然科学青年基金项目、省留学人员创新项目择优资助计划、省高校自然科学重点项目各1项，省转化研究院重点项目1项，校级科研基金3项，参与国家自然科学联合基金项目1项，发表SCI论文多篇。任中国药理学会抗炎免疫药理专业委员会首届青委会委员。

研究方向：1.肝脏疾病的病理机制及药物作用新靶点的发现

      2.生物药物PK/PD，药物靶向递呈系统（DDS）

电子邮箱：juntangshao@outlook.com

教育经历：

1.2007年-2011年 中国药科大学国家理科基地班理学学士

2.2011年-2016年 美国南加州大学医药科学博士

工作经历：
1.2016年-2019年 美国勃林格殷格翰制药公司药物代谢和动力学部门高级研究员

2.2019年至2020年 维多利亚老品牌vic3308药理学教研室校聘副教授

3.2020年至今 维多利亚老品牌vic3308药理学教研室副教授

学术荣誉：

入选安徽省“百人计划”青年项目，安徽省海外高层次人才引进计划

科研项目：

（1）安徽省留学人员创新项目择优资助计划项目，新型神经因子MANF改善酒精诱导的肝脂肪变性及机制，2020LCX020，5万元,主持。

（2）安徽省高校自然科学研究重点项目，肝细胞源性神经营养因子MANF通过调控精氨基琥珀酸合酶改善酒精诱导的肝脂肪变性，KJ2020A0137，6万元,主持。

（3）国家自然科学基金委员会青年项目, 882100629,神经因子MANF通过增强精氨基琥珀酸合酶活性发挥拮抗酒精性肝脏脂肪变性的作用，2022-2024，30万元，主持。

（4）维多利亚老品牌vic3308科研水平提升计划，2022xkjT002,肝细胞SAMHD1通过核转移抑制HCC进展和机制，2023-2025，30万元，主持。

（5）安徽省转化医学研究院科研基金项目,过氧化物酶6特异性酶检测方法的研发及在肝脏原发恶性肿瘤诊断中的应用,2024-2026，20万元，主持。

发表论文情况：

1)Juntang Shao#*, Wei Wang#, Shiyu Li, Guangfa Yin, Lili Han, Xinyu Wang, Meng Cai, Tao Yang, Ying Wang, Wenyan Qu, Yanhong Jiao, Peng Wang, Hanyang Xu, Xu Zhu, Songcheng Ying, Sa Xu, Qiang Sheng, Jian Fang, Tongcui Jiang, Chuansheng Wei, Yujun Shen, Yuxian Shen*. Nuclear Overexpression of SAMHD1 Induces M Phase Stalling in Hepatoma Cells and Suppresses HCC Progression by Interacting with the Cohesin Complex. Advanced Science. 2024 Dec 16:e2411988. doi: 10.1002/advs.202411988.

2)Han-Yang Xu, Yan-Hong Jiao, Shi-Yu Li, Xu Zhu, Sheng Wang, Yu-Yang Zhang, Yi-Jun Wei, Yu-Jun Shen, Wei Wang, Yu-Xian Shen*, Jun-Tang Shao*, Hepatocyte-derived MANF mitigates ethanol-induced liver steatosis in mice via enhancing ASS1 activity and activating AMPK pathway. Acta Pharmacologica Sinica. 2022: 1-12. doi: 10.1038/s41401-022-00920-8.

3)Xin-xin Ling, Hua Chen, Bei-bei Fu, Cheng-shao Ruan, Ming Pana, Kai Zhou, Zhi-rui Fang, Jun-tang Shao*, Feng-qin Zhu*, Shan Gao*, Xin-Ji-Er-Kang protects myocardial and renal injury in hypertensive heart failure in mice, Phytomedicine, 91, p.153675. doi: 10.1016/j.phymed.2021.153675.

4)Juntang Shao*, Jennica Zaro, Yuxian Shen*; Advances in Exosome-Based Drug Delivery and Tumor Targeting: From Tissue Distribution to Intracellular Fate, International Journal of Nanomedicine, 2020, 15: 9355-9371. doi: 10.2147/IJN.S281890.

5)Can Liu, Jun Liu, Juntang Shao, Cheng Huang, Xingliang Dai, Yujun Shen, Weishu Hou, Yuxian Shen, Yongqiang Yu; MAGED4B Promotes Glioma Progression via Inactivation of the TNF-α-induced Apoptotic Pathway by Down-regulating TRIM27 Expression. Neurosci Bull. 2022 Aug 20. doi: 10.1007/s12264-022-00926-6.

6)Goma Chhetri, Yanyan Liang, Juntang Shao, Dan Han, Yi Yang, Chao Hou, Peng Wang, XiaoFang Tao, Yujun Shen, Tongcui Jiang, Lijie Feng, Yuxian Shen*, Role of Mesencephalic Astrocyte-Derived Neurotrophic Factor in Alcohol-Induced Liver Injury, Oxidative Medicine and Cellular Longevity, 2020: 0-9034864.

7)Yuqian Liu#, Hsuan-Yao Wang#, Juntang Shao, Jennica Zaro, Wei-Chiang Shen*; Enhanced insulin receptor interaction by a bifunctional insulin-transferrin fusion protein: an approach to overcome insulin resistance, Scientific reports vol. 10,1 7724. 7 May. 2020, doi:10.1038/s41598-020-64731-9

8)Chao Hou†, Dong Wang†, Mingxia Zhao†, Petek Ballar, Xinru Zhang, Qiong Mei, Wei Wang, Xiang Li, Qiang Sheng, Jun Liu, Chuansheng Wei, Yujun Shen, Yi Yang, Peng Wang, Juntang Shao, Sa Xu, Fuyan Wang, Yang Sun*, Yuxian Shen* (2023). MANF brakes TLR4 signaling by competitively binding S100A8 with S100A9 to regulate macrophage phenotypes in hepatic fibrosis. Acta pharmaceutica Sinica. B, 13(10), 4234–4252.

9)Wang, Ting, Andrea Whitcher-Johnstone, Young_Sun Scaringella, Monica Keith-Luzzi, Juntang Shao, Mitchell E. Taub, and Tom S. Chan. Comparison of Commonly Used and New Methods to Determine Small Molecule Non-Specific Binding to Human Liver Microsomes. Journal of Pharmaceutical Sciences 113, no. 7 (2024): 1987-1995

10) Yanyan Liang, Qiong Mei, Enguang He, Petek Ballar, Chuansheng Wei, Yue Wang, Yue Dong, Jie Zhou, Xiaofang Tao, Wenyan Qu, Mingxia Zhao, Goma Chhetri, Limeng Wei, Juntang Shao, Yujun Shen, Jun Liu, Lijie Feng, Yuxian Shen MANF serves as a novel hepatocyte factor to promote liver regeneration after 2/3 partial hepatectomy via doubly targeting Wnt/β-catenin signaling. Cell Death & Disease 15, no. 9 (2024): 681.

11)Juntang Shao, Jennica L. Zaro, Wei-Chiang Shen*; Proinsulin–Transferrin Fusion Protein Exhibits a Prolonged and Selective Effect on the Control of Hepatic Glucose Production in an Experimental Model of TypeDiabetes., Molecular Pharmaceutics, 2016, 13(8): 2641-2646.

12)Yan Wang, Juntang Shao, Jennica L. Zaro, Wei-Chiang Shen*; Proinsulin-transferrin fusion protein as a novel long-acting insulin analog for the inhibition of hepatic glucose production. Diabetes, 2014, 63(5): 1779-1788.