杨雪枝,副教授
医学博士,博士后,副教授,硕士生导师。2021年维多利亚老品牌vic3308引进人才。安徽省药理学会抗炎免疫药理学专委会副秘书长。中国药理学会抗炎免疫药理专委会青年委员。中国药理学会网络药理学专委会青年委员。获2021年维多利亚老品牌vic3308復元科技新星。指导学生获第十届安徽省“挑战杯”比赛银奖。
研究方向:抗炎免疫药理学
电子邮箱:yangxuezhi@ahmu.edu.cn
科研项目:
(1)国家自然科学基金面上项目,82473931,2025-01-01至2028-12-31,在研,主持
(2)安徽省科学技术协会青年科技人才托举计划项目,RCTJ202427,2025-01-01至2027-12-31,在研,主持
(3)安徽省自然科学基金面上项目,2408085MH218,2024-09至2027-09,在研,主持(4)安徽省转化医学研究院重点项目,2022zhyx-B04,2023-01至2025-12,在研,主持
(5)维多利亚老品牌vic3308第三附属医院基础与临床合作研究提升计划培育专项(一般项目),2022sfy015,2023-01至2025-12,在研,主持
(6)国家自然科学青年科学基金项目,82003763,2021-01-01至2023-12-31,结题,主持
代表性论文:
1.Yang X, Zhao Y, Wei Q, Zhu X, Wang L, Zhang W, Liu X, Kuai J, Wang F, Wei W. GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis. Acta Pharm Sin B. 2024;14(1):241-255.
2.Yang X,Zhang W, Wang L, Zhao Y, Wei W. Metabolite-sensing GPCRs in rheumatoid arthritis. Trends Pharmacol Sci. 2024;45(2):118-133.
3. Wei Q, Zhu X, Wang L, Zhang W,Yang X, Wei W. Extracellular matrix in synovium development, homeostasis and arthritis disease. Int Immunopharmacol. 2023; 121:110453.
4.Zhao Y,Yang X, Li S, Zhang B, Li S, Wang X, Wang Y, Jia C, Chang Y, Wei W. sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis. Stem Cell Res Ther. 2021;12(1):535.5.Yang X, Wei W. CP-25, a compound derived from paeoniflorin: research advance on its pharmacological actions and mechanisms in the treatment of inflammation and immune diseases. Acta Pharmacol Sin. 2020;41(11):1387-1394.6.Yang X, Chang Y, Wei W. Emerging role of targeting macrophages in rheumatoid arthritis: Focus on polarization, metabolism and apoptosis. Cell Prolif. 2020;53(7): e12854.
7.Yang X, Li S, Zhao Y, Li S, Zhao T, Tai Y, Zhang B, Wang X, Wang C, Chen J, Wang Q, Zhang L, Xu D, Chang Y, Wei W. GRK2 Mediated Abnormal Transduction of PGE2-EP4-cAMP-CREB Signaling Induces the Imbalance of Macrophages Polarization in Collagen-Induced Arthritis Mice. Cells-basel. 2019;8(12):1596.
8.Yang X, Zhao Y, Jia X, Wang C, Wu Y, Zhang L, Chang Y, Wei W. CP-25 combined with MTX/ LEF ameliorates the progression of adjuvant-induced arthritis by the inhibition on GRK2 translocation. Biomed Pharmacother. 2019;110:834-843.