张贤政，讲师

研究方向：抗炎免疫药理学

联系电话：17398384975

电子邮箱：zxzhang@ahmu.edu.cn

办公室：临床药理研究所308室

教育经历：

(1) 2016-09至2021-06,维多利亚老品牌vic3308,药理学,博士（硕博连读）；

(2) 2012-09至2016-07,皖南医学院,制药工程,学士；

工作经历：

(1) 2024-10至今，维多利亚老品牌vic3308药学科学学院，教师

(2) 2021-08至2024-09,维多利亚老品牌vic3308第一附属医院，博士后；

学术兼职：

2023-11，安徽省药理学会抗炎免疫药理学专业委员会；

2024-04，《抗感染药学》青年编委

主持课题项目情况：

(1)国家自然科学基金委员会,青年科学基金项目, 82204403, HIF-1α通过调控糖酵解途径促进类风湿关节炎滑膜组织中IL-1β修饰NETs的形成, 2023-01-01至2025-12-31, 30万元,在研,主持；

(2)中国博士后基金会,中国博士后面上项目, 2022M720199,缺氧通过调控糖酵解途径促进类风湿关节炎滑膜组织中NETs的形成, 2021-03至2024-08, 8万元,结题,主持；

(3)安徽省教育厅,安徽省博士后研究人员科研活动资助经费, 2021B509, IgD/IgDR介导B淋巴细胞活化参与类风湿关节炎及靶向IgDR单抗的研究, 2021-08至2023-03, 5万元,结题,主持；

发表论文情况：

[1]. Wang H#, Zhao YC#, Xu L#, Zhang TJ#, Liu LH, Zhou MQ, Zhang H, Yang YN, Pan P, Jin L, Zhang ZW,Zhang XZ*, Zhang LL*. HIF-1α mediates mitochondrial damage by down-regulating ALKBH7 expression to promote the aberrant activation of FLS in rheumatoid arthritis. Acta Pharmacol Sin. 2025 Mar 26. doi: 10.1038/s41401-025- 01520-y.(IF=6.9)

[2]. Zhou MQ#, Jin L#, Wan P#, Sun CL#, Fang SQ, Chen Y, Tang YJ, Geng S, Liu LH, Zhang H, Yang YN, Liu QY, He WP, Zhang TJ, Zhao YC, Xu L, Tao L*, Zhao TY*,Zhang XZ*, Zhang LL*. Oleanolic Acid Derivative OA17 Inhibits Trophoblast Apoptosis by Suppressing HIF-1α Nuclear Translocation in SLE-Associated Adverse Pregnancy Outcomes.Phytomedicine,2025,accepted. (IF=6.7)[3]Zhang X#, Zhang Z#, Zhao Y#, Jin L#, Tai Y, Tang Y, Geng S, Zhang H, Zhai Y, Yang Y, Pan P, He P, Fang S, Sun C, Chen Y, Zhou M, Liu L, Wang H, Xu L, Zhang T, Hua J, Wang H, Zhang L.Sodium chloride promotes macrophage pyroptosis and aggravates rheumatoid arthritis by activating SGK1 through GABA receptors Slc6a12[J]. Int J Biol Sci. 2024; 20(8): 2922-2942. Article IF=9.2

[4]Zhao Y#, Wang H#, Jin L, Zhang Z, Liu L, Zhou M,Zhang X*, Zhang L*. Targeting fusion proteins of the interleukin family: A promising new strategy for the treatment of autoinflammatory diseases. Eur J Pharm Sci. 2024 Jan 1;192:106647. (IF=4.6)

[5] Jin L#, Zhang Z#, Pan P#, Zhao Y, Zhou M, Liu L, Zhai Y, Wang H, Xu L, Mei D, Zhang H, Yang Y, Hua J,Zhang X*, Zhang L*. Low-dose ethanol consumption inhibits neutrophil extracellular traps formation to alleviate rheumatoid arthritis. Commun Biol. 2023;6(1):1088.(IF=5.9)

[6] Zhang Z#, Jin L#, Liu L, Zhou M,Zhang X*, Zhang L*. The intricate relationship between autoimmunity disease and neutrophils death patterns: a love-hate story. Apoptosis. 2023;28(9-10):1259-1284. (IF=7.2)

[7] Hong Z#,Zhang X#, Zhang T#, Hu L, Liu R, Wang P, Wang H, Yu Q, Mei D, Xue Z, Zhang F, Zhang L. The ROS/GRK2/HIF-1α/NLRP3 Pathway Mediates Pyroptosis of Fibroblast-Like Synoviocytes and the Regulation of Monomer Derivatives of Paeoniflorin. Oxid Med Cell Longev. 2022;2022:4566851.(IF=7.31)

[8]Zhang X, Mei D, Wang H, Yu Q, Hong Z, Xu L, Ge J, Han L, Shu J, Liang F, Cai X, Zhu Y, Zhang F, Wang Q, Tai Y, Wang H, Zhang L, Wei W. hIgDFc-Ig inhibits B cell function by regulating the BCR-Syk-Btk-NF-κB signalling pathway in mice with collagen-induced arthritis. Pharmacol Res. 2021;173:105873.  Article IF=10.334

[9]Zhang X#, Mei D#, Zhang L, Wei W. Src Family Protein Kinase Controls the Fate of B Cells in Autoimmune Diseases. Inflammation. 2021;44(2):423-433.(IF=4.657)

[10] Han L#,Zhang XZ#, Wang C#, Tang XY, Zhu Y, Cai XY, Wu YJ, Shu JL, Wang QT, Chen JY, Chang Y, Wu HX, Zhang LL, Wei W. IgD-Fc-Ig fusion protein, a new biological agent, inhibits T cell function in CIA rats by inhibiting IgD-IgDR-Lck-NF-κB signaling pathways. Acta Pharmacol Sin. 2020 Jun;41(6):800-812.(IF=6.15)

[11] Shu JL#,Zhang XZ#, Han L#, Zhang F, Wu YJ, Tang XY, Wang C, Tai Y, Wang QT, Chen JY, Chang Y, Wu HX, Zhang LL, Wei W. Paeoniflorin-6'-O-benzene sulfonate alleviates collagen-induced arthritis in mice by downregulating BAFF-TRAF2-NF-κB signaling: comparison with biological agents. Acta Pharmacol Sin. 2019 Jun;40(6):801-813. Article(IF=5.064)